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OSIRIS (31 partners, FP7, 2007-2011) aims at developing Integrated Testing Strategies (ITS) fit for REACH to increase the use of non-testing information for regulatory decision making, and to effectively reduce animal testing. The operational procedures are developed, tested and disseminated that guide a transparent and scientifically sound evaluation of chemical substances in a risk-driven, context-specific and substance-tailored manner, and allow decision making to be built on information-rich combinations of novel non-testing and optimized experimental information. A major scientific challenge is to identify, reduce and manage the level of uncertainty. Accordingly, the envisaged decision-theory based framework will be designed to handle uncertainty explicitly, covering data, methods, models and decision making.

Participants: LU

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