Alessandra Pirovano
Alessandra Pirovano
Italy
General mechanisms in biotransformation of chemicals: Linking Michaelis (Km, Vmax) constants to lipophilicity
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1. Pirovano, A.; Brandmaier, S.; Huijbregts, M. A.; Ragas, A. M.; Veltman, K.; Hendriks, A. J., QSARs for estimating intrinsic hepatic clearance of organic chemicals in humans. Environmental toxicology and pharmacology 2016, 42, 190-197.
2. Pirovano, A. Quantifying biotransformation of xenobiotics in mammals. Radboud University, http://repository.ubn.ru.nl/handle/2066/147195, 2015.
3. Pirovano, A.; Brandmaier, S.; Huijbregts, M. A.; Ragas, A. M.; Veltman, K.; Hendriks, A. J., The utilisation of structural descriptors to predict metabolic constants of xenobiotics in mammals. Environmental toxicology and pharmacology 2015, 39 (1), 247-58.
4. Pirovano, A.; Huijbregts, M. A.; Ragas, A. M.; Veltman, K.; Hendriks, A. J., Mechanistically-based QSARs to describe metabolic constants in mammals. Altern. Lab. Anim. 2014, 42 (1), 59-69.
5. Pirovano, A.; Borile, N.; Jan Hendriks, A., A comparison of octanol-water partitioning between organic chemicals and their metabolites in mammals. Chemosphere 2012, 88 (8), 1036-41.
6. Pirovano, A.; Huijbregts, M. A.; Ragas, A. M.; Hendriks, A. J., Compound lipophilicity as a descriptor to predict binding affinity (1/K(m)) in mammals. Environ. Sci. Technol. 2012, 46 (9), 5168-74.
- “Biotransformation of chemicals: linking octanol-water partitioning to Michaelis constants to search for general mechanisms”.