- Name
-
Dr. José M. Navas
- Institute
-
Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria - Postal addresse
-
Department for the Environment,
Endocrine Disrupters and Toxicity of Contaminants (EDTC)
Ctra. de la Coruña Km 7.5,
E-28040 Madrid, Spain. - Phone
-
Phone: +34 – 913474155 Mobile: Fax: +34 – 913572293 - Web
-
Homepage: eMail: jmnavas@inia.es - About
Dr. José M. Navas is a research scientist at the Spanish National Institute for Agricultural, Food Research and Technology (INIA) in Madrid. He also acts as Director of the Department of Environment (80 staff members, 22 research scientists) and is head of the Endocrine Disruption and Toxicity of Contaminants research group. He obtained his PhD on the reproductive physiology of fish in 1997 at the University of Valencia. Thereafter he worked for two and a half years at the Helmholtz Centre for Environmental Research (UFZ) in Leipzig, Germany, in the framework of a Marie Curie fellowship. Here he began his in vitro work studying the mechanisms of toxicity and endocrine disruption of a variety of xenobiotics. After coming back to Spain with a Marie Curie Return Fellowship and obtaining several research contracts he received a permanent position at the INIA in 2005. From that time until the present Dr. Navas has concentrated on the study of the mechanisms underlying the action of endocrine disrupters and the toxicity of nanoparticles in fish. Fish and mammalian cell lines constitute a basic research tool in his group. Any alteration observed at the transcriptional, protein or enzymatic levels after exposure of the cells to the studied chemicals is detected and serves to elucidatethe mechanism of toxicity. These studies are carried out in parallel with detailed physico-chemical characterization of nanomaterials and chemical analysis, using next-generation techniques, to determine real exposure conditions. Currently, he is a Spanish representative at the OECD-WPMN and at the ECHA NM-WG and has also been named member of the ECVAM Scientific Advisory Committee (ESAC). - Curriculum Vitae
-
Education
BSc, Biology, July 29th, 1991. University of Salamanca. Spain.MSc. Biology, June 16th, 1992, University of Salamanca, Spain. Research work entitled “Exocrine pancreatic response to intraduodenal fatty acids and fats in rabbit”.
Ph. D. April 11th, 1997. PhD Thesis performed at the Institute of Aquaculture of Torre de la Sal (a public research institute of the Spanish Council for Scientific Research, Consejo Superior de Investigaciones Científicas, CSIC), working on aquaculture. The thesis was defended at the at the University of Valencia (Spain). Title: „Effect of the lipidic content of the diets fed by sea bass (Dicentrarchus labrax L.) broodstock on reproductive performance and egg quality“. The maximal calification was obtained.
Experience
Jun 1997 – Dec. 1999. Postdoc. Marie Curie Fellowship: Department of Aquatic Toxicology, UFZ (Umweltforschungszentrum, Centre for Environmental Research), Leipzig, Germany. Work on endocrine disrupters: the antiestrogenicity mediated by the aryl hydrocarbon receptor (AhR). Work performed mostly in vitro using primary hepatocytes. Jan. 2000 – Jun. 2000. Responsible for the Research and Development Department in a private company, in Spain. Jul. 2000 – May. 2001. Marie Curie Return Fellowship. Institute of Aquaculture of Torre de la Sal, CSIC. Work on endocrine disrupters in fish, working in vivo. Jun, 2001 – Dec. 2001. Return Contract from the Spanish Ministry of Education and Science (MEC) . INIA. Working on endocrine disruption and the environmental risk assessment of endocrine disrupters: in vitro and in vivo work. Jan. 2002 – Apr. 2005. Ramón & Cajal Contract (return contracts of MEC for high qualified scientists). INIA. Working on AhR induction caused by non classical AhR activators: use of fish cell lines and computer molecular modelization relating the in vitro results with the in silico results. May 2005 – present. Research Scientist at the INIA. Work on AhR and ER regulation, in vitro (fish cell lines and transformed cells) and in silico.
Jan. 2008-present Director of the Department of Environment at the INIA (90 persons, 23 research scientists). Management of the Department. - List of publications
-
SCI publications
Navas JM, Calvo JJ, López MA, de Dios MI. 1993.
Exocrine pancreatic response to intraduodenal fatty acids and fats in rabbit.
Comparative Biochemistry and Physiology 363A: 461 – 474Navas JM, Anglade I, Bailhache Th, Pakdel F, Breton B, Jégo P, Kah O.1995.
Do gonadotrophin-releasing hormone neurons express estrogen receptors in the rainbow trout? A double immunohistochemical study.
The Journal of Comparative Neurology 363: 461-474Linard B,Anglade I, Corio M, Navas JM,Pakdel F, Saligaut Ch, Kah O. 1996.
Estrogen receptors are expressed in a subset of tyrosine hydroxylase-positive neurons of the anteroir preoptic region in the rainbow trout.
Neuroendocrinology 63: 156 – 165Navas JM, Bruce M, Thrush M, Farndale, Bromage N, Zanuy S, Carrillo, Bell JG, Ramos J. 1997.
The impact of seasonal alteration in the lipid composition of broodstock diets on egg quality in the European sea bass
Journal of Fish Biology 51: 760 – 773Bell JG, Farndale BM, Bruce MP, Navas JM, Carrillo M. 1997.
Effects of broodstock dietary lipid on fatty acid compositions of eggs from sea bass (Dicentrarchus labrax).
Aquaculture 149: 107 – 119Navas JM, Mañanós E, Ramos J, Zanuy S, Carrillo M, Thrush M, Zohar J, Bromage N. 1998.
Effect of dietary lipid composition on vitellogenin, 17ß-estradiol and gonadotropin plasma levels and spawning performance in captive sea bass (Dicentrarchus labrax L.).
Aquaculture 165: 65 – 79Carnevali O, Mosconi G, Centonze F, Navas JM, Zanuy S, Carrillo M. 1998.
Influence of diet on yolk protein components in sea bass, Dicentrarchus labrax
Scientia Marina 62: 311 – 318Navas JM, Segner H.1998.
Antiestrogenic activity of anthropogenic and natural chemicals
Environmental Science and Pollution Research 5: 75 – 82Schrag B, Ensenbach U, Navas JM, Segner H. 1998.
Evaluation of xenoestrogenic effects in fish on different organization levels
Reproductive Toxicology Advances in Experimental Medicine and Biology 444: 207-214Navas JM, González-Mazo E, Wenzel A, Gómez-Parra A, Segner H. 1999.
Linear alkylbenzene sulfonates and the intermediate products from their degradation are not estrogenic
Marine Pollution Bulletin 38: 880 – 884Navas JM, Segner H. 2000.
Antiestrogenicity of polyaromatic hydrocarbons is mediated through their interaction with the aryl hydrocarbon receptor
Aquatic Toxicology 51: 79 – 92Carrillo M, Zanuy S, Oyen F, Cerdá J, Navas JM, Ramos J. 2000.
Some criteria of the quality of the progenie as indicators of physiological broodstock fitness
Cahiers Options Méditerranées 47: 61 – 74Navas JM, Segner H. 2000
Modulation of 7-ethoxyresorufin-O-deethylase (EROD) activity by estradiol and octylphenol.
Marine Environmental Research 50: 157 – 162Navas JM, Thrush M, Zanuy S, Ramos J, Bromage N, Carrillo M. 2001.
Relationship between fatty acid composition and quality of eggs of sea bass (Dicentrarchus labrax L.) broodstock fed with different diets
Scientia Marina 65: 11 – 19Navas JM, Segner H. 2001.
Estrogen-mediated suppression of cytochrome P4501A (CYP1A) expression in rainbow trout hepatocytes: role of estrogen receptor
Chemico Biological Interactions 138: 285 – 298Navas JM, Chana A, Herradón B, Segner H. 2003.
Induction of CYP1A by a non coplanar compound, 1-benzylimidazole.
Environmental Toxicology and Chemistry 22: 830 – 836Segner H, Navas JM, Schäfers C, Wenzel A. 2003.
Relative potencies of three estrogenic compounds in in vitro screening assays and in a definitive zebrafish reproduction test.
Ecotoxicology and Environmental Safety 54: 315 – 322Navas JM, Zanuy S, Segner H, Carrillo M. 2004.
ß-naphthoflavone alters normal plasma levels of vitellogenin, 17ß-estradiol and luteinizing hormone in sea bass broodstock
Aquatic Toxicology 67: 337 – 345Navas JM, Mañanós E, Ramos J, Zanuy S, Carrillo M. 2004.
Luteinizing hormone plasma levels in male European sea bass (Dicentrarchus labrax L.) feeding diets with different fatty acid composition
Ciencias Marinas 30: 527 – 536Montero A, Alonso M, Benito E, Chana A, Mann E, Navas JM, Herradón B. 2004.
Inhibition of Calpain I by 2,2’-Biphenyl derivatives with additional aromatic rings.
Bioorganics Medicinal Chemistry Letters. 14/11: 2753-2757Navas JM, Chana A, Herradón B, Segner H. 2004.
Induction of cytochrome P4501A (CYP1A) by clotrimazole, a non-planar aromatic compound. Computational studies on structural features of clotrimazole and related imidazole derivatives.
Life Sciences 76: 699 – 714
Babín M, Casado S, Chana A, Herradón B, Segner H, Tarazona JV, Navas JM. 2005.
Cytochrome P4501A induction caused by the imidazole derivative Prochloraz in a rainbow trout cell line.
Toxicology. In Vitro 19: 899-902.Navas JM, Merino R, Jiménez B, Rivera J, Abad E, Zanuy S, Carrillo M. 2005.
Organochlorine compounds in liver and concentrations of vitellogenin and 17ß-estradiol in plasma of sea bass fed with a commercial or with a natural diet.
Aquatic Toxicology 75: 306-315Navas JM, Babín M, Casado S, Fernández C, Tarazona JV. 2006.
The Prestige oil spill: A laboratory study about the toxicity of the water-soluble fraction of the fuel-oil.
Marine Environmental Research 62 S1: S352 – S355.Casado S, Alonso M, Herradón B, Navas JM. 2006.
Activation of the aryl hydrocarbon receptor by carbaryl: Computational evidence of the ability of carbaryl to assume a planar conformation.
Environmental Toxicology and Chemistry 25: 3141 – 3147.Navas JM, Segner H. 2006.
Vitellogenin synthesis in primary cultures of fish liver cells as endpoint for in vitro screening of the (anti)estrogenic activity of chemical substances
Aquatic Toxicology 80: 1 – 22.Boronat S, Casado S, Navas JM, Piña B. 2007.
Modulation of aryl hydrocarbon receptor transactivation by carbaryl, a non convencional ligand.
The FEBS Journal 274: 3327 – 3339.Jos A, Segner H, Herradón B, Repetto G, Navas JM. 2007.
Induction of EROD activity by 1-phenylimidazole in rainbow trout cultured hepatocytes: a comparative study with β-naphthoflavone.
Toxicology in Vitro 21: 1307 – 1310.Navas JM, Segner H. 2008
In vitro screening of the antiestrogenic activity of chemicals
Expert Opinion on Drug Metabolism & Toxicology 4(5): 605-617.Alonso M, Casado S, Miranda C, Tarazona JV, Navas JM, Herradón B. 2008
Decabromobiphenyl (PBB 209) activates de aryl hydrocarbon receptor while decachlorobiphenyl (PCB 209) is inactive. Experimental evidences and computational rationalization of the different behaviour of some halogenated biphenyls.
Chemical Research in Toxicology 21: 643 – 658. )González-Doncel M, González L, Fernández-Torija C, Navas JM, Tarazona JV. 2008.
Toxic effects of an oil spill on fish early life stages may not be exclusively associated to PAHs: Studies with Prestige oil and medaka (Oryzias latipes).
Aquatic Toxicology 87: 280-288.Pablos MV, Fernández C, Babín MM, Navas JM, Carbonell G, Martini F, García-Hortigüela P, Tarazona JV. 2009. Use of a novel battery of bioassays for the biological characterisation of hazardous wastes.
Ecotoxicology and Environmental Safety 72: 1594 – 1600.Bosch C, Olivares A, Faria M, Navas JM, del Olmo I, Grimalt JO, Piña B, Barata C. 2009.
Identification of water soluble and particle bound compounds causing sublethal toxic effects. A field study on sediments affected by a chlor-alkali industry.
Aquatic Toxicology 94: 16 – 27 Clave: A (2008 IF: 2.590)Bosch C, Olivares A, Faria M, Navas JM, del Olmo I, Grimalt JO, Piña B, Barata C. 2009.
Identification of water soluble and particle bound compounds causing sublethal toxic effects. A field study on sediments affected by a chlor-alkali industry.
Aquatic Toxicology 94: 16 – 27Sánchez AI, Hernando MD, Vaquero JJ, García E, Navas JM. 2010.
Hazard assessment of alternatives to Dicofol.
Journal of Environmental Protection 1: 231-241Fernández-Cruz, M.L., Valdehita, A., Alonso, M., Mann, E., Herradón, B., Navas, J.M. 2011
Biological and chemical studies on the aryl hydrocarbon receptor induction by the p53 inhibitor pifithrin-α and its condensation product pifithrin-β.
Life Sciences 88: 774-783De la Casa-Resino I, Valdehita A, Soler F, Navas JM, Pérez-López M. 2012.
Estrogenic effects caused by oral administration of atrazine in European quail (Coturnix coturnix coturnix)
Comparative Biochemistry and Physiology, Part C 156: 159-165.Hernando MD, Rosenkranz P, Ulaszewska MM, Fernández-Cruz ML, Fenández-Alba AR, Navas JM. 2012.
Dose-response effects in vitro of poly(amidoamine) dendrimers (amino-terminated and surface modified with [N-(2-hydroxydodecyl)] groups) and quantitative determination by a liquid chromatography- hybrid quadrupole/time of flight mass spectrometry based method.
Analytical and Bioanalytical Chemistry 404 Pages: 2749-2763Mezcua M, Martínez-Uroz MA, Gómez-Ramos MM, Gómez MJ, Navas JM, Fernández-Alba AR. 2012
Analysis of synthetic endocrine-disrupting chemicals in food: A review
Talanta 100: 90-106.Quesada-García A, Valdehita A, Fernández-Cruz ML, Leal E, Sánchez E, Martín-Belinchón M, Cerdá-Reverter JM, Navas JM. 2012.
Assessment of estrogenic and thyrogenic activities in fish feeds
Aquaculture 338-341: 172-180Rosenkranz P, Fernández-Cruz ML, Navas JM. 2012.
Cytotoxicty of cerium oxide micro and nanoparticles to two different cell lines.
Toxicology in vitro 26: 888-896.Valdehita A, Fernández-Cruz ML, Torrent F, Navas JM. 2012.
Differences in the induction of CYP1A and related genes in cultured rainbow trout Oncorhynchus mykiss. Additional considerations for the use of EROD activity as biomarker.
Journal of Fish Biology. 81: 270-287.Campos B, Rivetti C, Rosenkranz P, Navas JM, Barata C. 2013. Effects of nanoparticles of TiO2 on food depletion and life-history responses of Daphnia magna.
Aquatic Toxicology 130-131: 174-183
Fernández-Cruz ML, Lammel T, Connolly M, Conde E, Barrado A, Sylvain D, Pérez Y, Fernández M, Furger C, Navas JM. 2013.
Comparative cytotoxicity induced by bulk and nanoparticulated ZnO in the fish and human hepatoma cell lines PLHC-1 and Hep G2.
Nanotoxicology doi 10.3109/17435390.2012.676098Malhão F, Urbatzka R, Navas JM, Cruzeiro C, Monteiro RAF, Rocha E. 2013.
Cytological, immunocytochemical, ultrastructural and growth characterization of the rainbow trout liver cell line RTL-W1
Tissue and Cell. 45: 159-174Song L, Connolly M, Fernández-Cruz ML, Vijver MG, Fernández M, Conde E, de Snoo GR, Peijnenburg WJGM, Navas JM. 2013.
Species specific toxicity of copper nanoparticles among mammalian and piscine cell lines.
Nanotoxicology. DOI: 10.3109/17435390.2013.790997De la Casa-Resino I, Hernández-Moreno D, Navas JM, Soler F, Pérez-López M. 2013.
Non-destructive multibiomarker approach in European quail (Coturnix coturnix coturnix) exposed to the herbicide atrazine.
Archives of Environmental Contamination and Toxicology. DOI: 10.1007/s00244-013-9907-3.Quesada-García A, Valdehita A, Torrent F, Villarroel M, Hernando D, Navas JM. 2013.
Use of fish farms to assess river contamination: combining biomarker responses, active biomonitoring, and chemical analysis.
Aquatic Toxicology. Under revisionLammel T, Boisseaux P, Fernández-Cruz ML, Navas JM.2013.
Internalization and cytotoxicity of graphene oxide and carboxyl graphene nanoplatelets in the human hepatocellular carcinoma cell line HepG2.
Particle and Fiber Toxicology. Under revisionConnolly M, Pérez Y, Mann E, Herradón B, Fernández-Cruz ML, Navas JM. 2013.
Peptide-biphenyl hybrid-capped AuNPs: stability and biocompatibility under cell culture conditions.
Nanoscale Research Letters. Under revision.Publications not included in SCI: congress proceedings.
Navas JM, Thrush M, Ramos J, Bruce M, Zanuy S, Carrrillo M, Bromage N. 1995. The effect of seasonal alteration in the lipid composition of broodstock diets on egg quality in the european sea bass (Dicentrarchus labrax). Proceedings of the 5th. Int. Symp. of Reprod. Physiol. of Fish. Austin, Texas, July 2-8, 1995. Goetz F and Thomas P, eds. pp.: 108-110.
Navas JM, Mañanós E, Thrush M, Ramos J, Zanuy S, Carrillo M, Zohar Y, Bromage N. 1995. Effect of the lipid composition of the diet on the hormonal levels and spawning performance of sea bass (Dicentrarchus labrax). Proceedings of the 5th. Int. Symp. of Reprod. Physiol. of Fish. Austin, Texas, July 2-8, 1995. Goetz F and Thomas P, eds. pp.: 131.
Linard B, Anglade I, Bennani S, Salbert G, Navas JM, Bailhache T, Pakdel F, Jégo P, Valotaire Y, Saligaut C, Kah O. 1995. Some insights into sex steroid feedback mechanisms in the trout. Proceedings of the 5th. Int. Symp. of Reprod. Physiol. of Fish. Austin, Texas, July 2-8, 1995. Goetz F and Thomas P, eds. pp.: 49-51.
Ensenbach U, Schrag B, Navas JM, Segner H. 1998. Evaluation of xenoestrogenic effects in fish on different organisation levels. Proceedings of the Workshop on Reproductive Toxicology. Granada, October 8-10, 1997. pp.:85.
Navas JM, Thrush M, Ramos J, Zanuy S, Carrillo M, Bromage N. 1993. Calidad de puesta y niveles plasmáticos de vitelogenina en reproductores de lubina (Dicentrarchus labrax) mantenidos con diferentes dietas. Actas del IV Cong. Nac. Acuic. Isla de Arosa, 1993. Cerviño A, Landin A, de Coo A, Gerra A and Torre M, eds. pp.: 103-108.
Thrush M, Navas JM, Ramos J, Bromage N, Carrillo M. 1993. The effect of artificial diets on lipid class and total fatty acid composition of cultured sea bass (Dicentrarchus labrax)eggs. Actas del IV Cong. Nac. Acuic. Isla de Arosa, 1993. Cerviño A, Landin A, de Coo A, Gerra A and Torre M, eds. pp.: 37-42.
Ramos J, Thrush M, Navas JM, Zanuy S, Carrillo M, Bromage N. 1993. Efecto del enriquecimiento lipídico de dietas artificiales sobre el crecimiento, fecundidad y calidad de puesta en la lubina (Dicentrarchus labrax).Actas del IV Cong. Nac. Acuic. Isla de Arosa, 1993. Cerviño A, Landin A, de Coo A, Gerra A and Torre M, eds. pp.: 13-18.
Books/book chapters
Ensenbach U, Schrag B, Navas JM, Segner H. 1998. Evaluation of xenoestrogenic effects in fish on different organisation levels. In: „Reproductive Toxicology“. Plenum Press, New York. Del Mazo, edr. pp.:207-214. (CL)
Navas JM, Schrag B, Segner H. 1999. Avances en ecotoxicología marina. I. Toxicidad de compuestos químicos en el medio acuático: xenobióticos y alteraciones endocrinas. In: Patología, Fisiología y Biotoxicología en Acuicultura. Serv. Public. Univ. Cádiz. Sarasquete C, Muñoz-Cueto JA and González de Canales ML, eds. Pp.: 33-43. ISBN: 84-00-07851-1. (CL)
Navas JM. 2001. Disrupción Endocrina en el Sistema Reproductor de Peces . En: “Memorias de las segundas jornadas teórico-prácticas de acuicultura. Patología y biotecnología de la reproducción”. Serv. Public. Univ. Valencia. Asturiano JF, Edr. ISBN: 84-95219-90-5. (CL)
Vega M, Pablos MV, Navas JM, Tarazona JV. 2002. A metabolism-based Biomagnification model for the prediction of concentrations and effects of dioxins in high trophic levels. En: “Organohalogen compounds” Vol: 59. Ribera J, Llerena JJ, Abad E, Edrs. Pp: 187-190. ISBN: 84-607-5182-1. (CL)
Navas JM, Chana A, Herradón B, Segner H. 2002. Activation of the aryl hydrocarbon receptor by 1-benzylimidazole: a non-coplanar compound. En: “Organohalogen compounds” Vol: 59. Ribera J, Llerena JJ, Abad E, Edrs. Pp: 437-440. ISBN: 84-607-5182-1. (CL)
Navas, J.M., Zanuy, S., Segner, H., Carrillo, M. 2002. Antiestrogenic effects of ß-naphthoflavone on the hormonal regulation of reproduction in sea bass. In: Proceedings of the 21st Conference of European Comparative Endocrinologists. Bonn(Germany), August 26-30, 2002. Eds R. Keller, H. Dircksen, D. Sedlmeier, H. Vaudry. Bologna: Monduzzi Editore, International Proceeding Division. Volume. Pp: 71-74. ISBN 88-323-2826-7. CD ISBN 88-323-2827-5. (CL)
Navas JM. Efecto del Contenido Lipídico de las Dietas administradas a Reproductores de Lubina (Dicentrarchus labrax L.) sobre el Proceso Reproductor y sobre la Calidad y Composición de los Huevos. Tesis doctoral. 2004. Servicio de Publicaciones de la Universidad de Valencia. ISBN: 84-370-5760-4. (L)
Tarazona, J.V., Pablos, M.V, Navas, J.M. Addendum Volume III B.8 Ecotoxicology. July 2003. pp. 1-94. In 1997 “Alachlor - Monograph prepared in the context of the inclusion of the active substance in Annex I of the Council Directive 91/414/EC”. 4 Vol. 837 pp. García-Baudín, J.M.ª and Alonso-Prados, J. L. (coordinators).
Navas JM. “Los perturbadores endocrinos y sus posibles efectos en la reproducción de peces cultivados”. In: “La reproducción de los peces: aspectos básicos y sus aplicaciones en
acuicultura. 718pp. Publicaciones Científicas y Tecnológicas del Observatorio de Acuicultura. MA Carrillo Estévez and JE de los Monteros, Coordinators. DiScript Preimpresión, S.L., Madrid, España. Edited by Observatorio Español de Acuicultura (OESA) 2009.
